Glowing Zebrafish: Making New Myelin!

Jun 30 2013

One the critical needs is a medication to repair myelin.   The process of making new myelin is called remyelination.  Researchers in Korea have worked on genetically-engineered zebrafish to develop a way to study remyelination for multiple sclerosis.  In this fish model,  exposure to the common antibiotic metronidazole (Flagyl) causes loss of the myelin-making cells (oligodendrocytes)  and demyelination within 2 days.  However, removal of the antibiotic allows for “efficient” remyelination within 7 days.  Using a fluorescent protein, mCherry,  active remyelination and demyelination can actually be visualized glowing in the living zebrafish.   This cool fish model could be important to quickly test treatments for myelin repair.

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BY: Barry Singer, MD DATE: June 30, 2013 TOPIC: MS Research News