RSSShareTwitterYouTube

Archive for ‘Podcasts

Oct 14 2021 MS Living Well Podcast: Multiple Sclerosis Clinical Trials

Image: Rawpixel

Interested in improving MS care? Participating in a clinical trial may have personal advantages and may help others in the future. Trial design discussed including whether or not a placebo (no treatment) will be used. Criteria needed to enroll in a clinical study called inclusion and exclusion criteria explained. Key elements of clinical trials outlined including multiple safety measures and informed consent.

Current clinical trials in multiple sclerosis are covered including using highly effective treatment early for someone living with multiple sclerosis. Current studies in progressive MS and remyelination shared. Compounds highlighted include BTK inhibitors, masitinib, ibudilast, simvastatin and gold nanocrystals.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Jiwon Oh MD PhD

Jiwon Oh MD PhD is the Director of the BARLO MS Centre at St. Michael’s Hospital in Toronto. She is an Associate Professor of Neurology University of Toronto. Dr. Oh’s research focuses on developing advanced imaging techniques of the spinal cord and brain for use in clinical settings. She is the principal investigator  of local and collaborative, multi-center MRI studies. Dr. Oh is the lead of the Canadian National Progression Cohort, which is focused on better understanding progression in MS.  She completed her undergraduate degree at the University of Toronto and medical school from Queen’s University. Dr. Oh completed her residency at the University of Toronto, PhD in Public Health at John Hopkins and neuroimmunology fellowship at John Hopkins.

Robert Bermel MD

Robert Bermel MD is a neurologist specializing in multiple sclerosis at the Mellen Center for Multiple Sclerosis at Cleveland Clinic. He received a medical degree with thesis honors from the State University of New York at Buffalo. Dr. Bermel completed his neurology residency training and served as Chief Resident at Cleveland Clinic. He was funded as a National MS Society postdoctoral fellow in clinical neuroimmunology and advanced imaging at Cleveland Clinic. Dr. Bermel cares for patients, conducts imaging research, and an investigator in multiple clinical trials at the Mellen Center. His current research interests focus on the identification of advanced imaging methods to evaluate and improve recovery from inflammatory demyelinating disease.

This specific episode is sponsored by Sanofi Genzyme.

 

Apr 6 2021 MS Living Well Podcast: Future Look: From Diagnosis to Tracking Multiple Sclerosis

Image: Rawpixel

Cutting-edge research is revolutionizing how multiple sclerosis is diagnosed and monitored.  The central vein sign on MRI may soon be a key way of confirming if someone has multiple sclerosis versus other conditions such as migraine, vasculitis, neurosarcoidosis and blockage of small blood vessels (from age, smoking and hypertension).

Multiple sclerosis lesions with visible dark veins inside, called Central Vein Sign. Image: Daniel Reich MD PhD

Early clues on MRI imaging are shared in people with evidence of MS prior to developing symptoms (called radiologically isolated syndrome or RIS). New imaging techniques in development visualize changes in progressive multiple sclerosis like slowly-expanding lesions and inflammatory cells called microglia.  Dr. Daniel Reich from the NIH covers additional topics from routine MRI monitoring of the brain and spinal cord to remyelination imaging.

With incredible medical advances, some people that were considered to have multiple sclerosis are now diagnosed with neuromyelitis optica (NMO) and MOG Antibody Disease (MOGAD).  Dr. Sean Pittock from Mayo Clinic shares how NMO and MOGAD are different from multiple sclerosis and reviews the alternate approaches to treatment including the 3 FDA-approved treatments for NMO, Soliris (eculizumab), Uplinza (inebilizumab) and Enspyrng (satralizumab).  Latest research in screening spinal fluid and blood for clues of multiple sclerosis discussed to improve diagnosis and monitoring of the disease.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Daniel Reich MD PhD

Daniel Reich MD PhD is the Chief of the Translational Neuroradiology Section of the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH).  He obtained his undergraduate degree in math and physics at Yale, PhD in neuroscience at The Rockefeller University and MD degree at Cornell.  Dr. Reich completed residencies in both neurology and diagnostic radiology and a neuroradiology fellowship at John Hopkins Hospital.

Sean Pittock MD

Sean Pittock MD is a Professor of Neurology at Mayo Clinic.  His is the Director of Mayo Clinic’s Center for Multiple Sclerosis and Autoimmune Neurology and Director of Mayo’s Neuroimmunology Research Laboratory. He earned his medical degree from University College Dublin, post-doctoral degree at the Royal College of Surgeons in Ireland followed by residency and fellowship at Mayo Clinic in Rochester, Minnesota.

Mar 23 2021 MS Living Well Podcast: Wellness & Multiple Sclerosis

Image: Rawpixel

Wellness is a proactive approach to living with multiple sclerosis. Wellness complements routine neurological care, which is often reactive to new relapses, symptoms and disease progression.  Nutrition reviewed including diets such as intermittent fasting, paleo and Wahls Protocol.  Great physical health relies on keeping up with routine cancer screenings and vaccinations. Options for protecting cognitive health and improving mental health are highlighted. Ways to improve social and spiritual connections are shared.

Successful exercise strategies presented for an array of MS disability levels.  Information given on how to balance the need for increased muscle strength with concerns of overexertion and fatigue. The role of physical, occupational and speech therapy for people with MS reviewed.  The latest and future technology explored including zero-gravity treadmills, electronic foot braces, robotic exoskeletons and implantable microstimulators.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Riley Bove MD is an Assistant Professor of Neurology at the University of California-San Francisco.  Her multiple sclerosis research focuses on hormones and digital medicine. Dr. Bove started her studies in anthropology at Harvard and then global studies on a Fulbright scholarship. She returned to Harvard for medical school and then completed her residency at Massachusetts General Hospital and Brigham Women’s hospital in Boston.  She completed a clinical research fellowship at the Partners MS Center and a Masters Degree through Harvard Medical School’s Clinical Investigator Training Program.

Ben Thrower MD is the medical director of the Andrew C. Carlos MS Institute at Shepherd Center, a leading rehabilitation hospital in Atlanta. He completed his medical degree at University of Florida and neurology residency at the University of Texas in San Antonio. Dr. Thrower is a Clinical Instructor of Neurology at Emory University and participates actively in clinical research. He serves on the board of directors of the Georgia Chapter of the National MS Society and has served on the board for the Consortium of Multiple Sclerosis Centers. In 2005, he was the first physician inductee into the Georgia Chapter of the National MS Society Volunteer Hall of Fame.

Mar 9 2021 MS Living Well Podcast: Anxiety, Depression & Multiple Sclerosis

Photo: Rawpixel

Struggling with anxiety or depression? Over half of people living with multiple sclerosis can experience depression and up to 40% have anxiety. Both psychological and physical symptoms that people with MS experience are explained. Causes for these mood disorders are discussed including immune inflammation in the brain, adaptation to having a chronic disease and medication side effects such as interferons and steroids.  People with depression are at higher rate of developing multiple sclerosis. In addition, depression is associated with more disability for those living with MS which may be due to not taking medications properly, smoking, not exercising and even chemical brain changes.

Therapy options explored including meditation (including mindfulness), stress reduction, cognitive behavioral therapy and virtual platforms. Prescription medication options for both anxiety and depression covered including benefits and risks including dependence. Experts share resources and hope for those living with MS with severe depression including suicidal thoughts.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Amy Sullivan PsyD ABPP

Amy Sullivan PsyD, ABPP is a board-certified, staff clinical health psychologist and the Director of Behavioral Medicine at the Mellen Center for MS Treatment and Research at the Cleveland Clinic. Dr. Sullivan received her doctorate degree at Argosy University-Atlanta, her internship at the University of Cincinnati, and her fellowship at the Cleveland Clinic in Pain Medicine. She is also the principal investigator for several clinical trials at the Mellen Center, where her research interests are focused on MS, pain, exercise and behavioral medicine.

Adam Kaplin MD PhD

Adam Kaplin MD PhD is the Chief Scientific Officer of MyMD Pharmaceuticals Inc. since December 2020.  He completed his undergraduate degree from Yale University, graduating magna cum laude, and obtained both his MD and PhD degrees at Johns Hopkins. Dr. Kaplin complete his residency in psychiatry at Johns Hopkins Hospital, where he served as the chief resident of psychiatry. He served as an Assistant Professor of Psychiatry and Behavioral Sciences at John Hopkins and the principal psychiatric consultant to the John Hopkins MS Center. He remains as adjunct faculty at John Hopkins.

Feb 23 2021 MS Living Well Podcast: Progressive Multiple Sclerosis

Mark Webb, wheelchair rugby player and Head of Communications for Shift.ms

Progressive multiple sclerosis can be a worrisome diagnosis, filled with questions about one’s personal future including independence. In this podcast, Mark Webb shares his personal story of transition to secondary progressive multiple sclerosis with brilliant humor, incredible resiliency and tenacious optimism. He explains how MS has affected his career from Euro Disney to Head of Communications at Shift.ms, a global online MS community. He candidly describes the impact of the disease on his functioning including cognition, mobility and bladder and how he has adapted to these obstacles. Mark reflects on his acceptance of progressive MS and emphasizes his motivation to make a difference for himself, his family and the MS community.

Dr. Gavin Giovannoni describes in the podcast primary progressive MS (PPMS), secondary progressive MS (SPMS) and active secondary progressive MS and whether or not these are truly different conditions. He moves beyond labels and explains that people with progressive disease, even those with limited mobility, can still be at risk of relapses affecting vision and arms. Continuing, switching or stopping disease-modifying therapy in progressive multiple sclerosis patients are covered. The impact of early MS damage, aging and ongoing, smoldering inflammation on progressive disease is described. Progressive multiple sclerosis treatments in clinical trials are highlighted including masitinib, BTK inhibitors, ibudilast, simvastatin, biotin, lipoic acid and remyelination strategies.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Mark Webb

Mark Webb is Head of Communications for Shift.ms, an online community of over 38,000 people living with MS. Mark lives with secondary progressive multiple sclerosis and first developed MS symptoms back in 1992. He’s a blog writer: One Man and His Catheters, public speaker and rugby wheelchair player. Mark lives in the U.K. with wife and 2 sons.

Dr. Gavin Giovannoni

Gavin Giovannoni MBBCh, PhD, FCP, FRCP, FRCPath is the Chair of Neurology of the Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry at Queen Mary University of London. Professor Giovannoni completed his medical training and neurology training in South Africa. In addition, he completed a PhD in immunology from the University of London in 1998.  He is particularly interested in clinical issues related to optimizing MS disease modifying therapies including progressive disease.

Feb 9 2021 MS Living Well Podcast: Multiple Sclerosis Numbness & Pain: Relief Options

Photo: Rafal Szczawinski on Unsplash

People living with multiple sclerosis often experience chronic numbness, burning, tingling and pins-and-needles sensations.  In a recent study, 70% of people with MS reported numbness and tingling and 55% reported pain associated with relapses.  MS neurologists explain typical symptoms for brain and spinal cord MS attacks compared to a pinched nerve in the back (like sciatica) or neuropathy.  Lhermitte’s sign (shocks down the spine when moving neck) and Uhthoff’s phenomenon (symptoms like numbness when overheated) are covered since frequently the first symptoms of multiple sclerosis. Options for relief from burning, tingling and pins-and-needles reviewed including medications such as Neurontin (gabapentin), Lyrica (pregabalin), Elavil (amitriptyline) and Cymbalta (duloxetine).

Painful MS syndromes including trigeminal neuralgia, MS hug and flexor and extensor spasms are individually reviewed with numerous specific treatment options.  MS experts also share options to alleviate painful muscle cramps and spasms as well as musculoskeletal pain such as low back pain.  The podcast aims to provide awareness and options for relief so that people living with MS can better communicate with their doctors to improve their care.

Barry Singer MD, director of The MS Center for Innovations in Care, interviews:

Mitzi Joi Williams MD

Mitzi Joi Williams, MD is the Founder and CEO of Joi Life Wellness Group Multiple Sclerosis Center.  She completed her undergraduate degree in neuroscience and behavioral biology at Emory University and her medical degree at Morehouse School of Medicine in Atlanta, Georgia.  Dr.  Williams subsequently did her neurology residency (including serving as chief resident) and multiple sclerosis fellowship at Georgia Health Sciences University (formerly MCG) in Augusta, GA.  She is the author of MS Made Simple: The Essential Guide to Understanding Your Multiple Sclerosis Diagnosis.

Brandon Beaber MD

Brandon Beaber MD is a neurologist specializing in multiple sclerosis at Kaiser Permanente in Los Angeles.  He completed his undergraduate degree from University of California-Berkley followed by Medical School at Drexel University in Philadelphia. He completed his neurology residency at Kaiser Permanente’s Los Angeles Medical Center (LAMC) and fellowship in multiple sclerosis and neuroimmunology at University of Southern California.  He authored Resilience in the Face of Multiple Sclerosis and regularly posts educational videos for people living with MS on his YouTube channel.

Jan 26 2021 MS Living Well Podcast: Multiple Sclerosis & Vaccines including COVID-19

Barry Singer MD, MS Living Well podcast host, receiving 1st Pfizer COVID-19 vaccination on December 17, 2020.

Vaccinations have been extremely effective in saving people from numerous fatal diseases such as measles, polio, hepatitis B, diphtheria and tetanus. Currently, the COVID-19 pandemic has been raging with almost 100 million people affected and over 2.1 million people dead. We again turn to our medical researchers. Recently available COVID-19 vaccines provide new optimism.  People living with multiple sclerosis have numerous questions regarding whether these COVID-19 vaccines against the SARS-Cov-2 virus are safe and effective for them. Both mRNA and adenovirus COVID-19 vaccines are explained on this podcast and concerns regarding vaccinating MS patients addressed.

The podcast covers types of vaccines people with multiple sclerosis should avoid and which vaccines are safe. The question whether vaccines can trigger MS attacks is tackled. Vaccines for measles-mumps-rubella (MMR), chicken pox (varicella), hepatitis B and influenza (flu) are individually reviewed.  Multiple sclerosis disease-modifying therapies (DMTs) can suppress the immune system and potentially impact whether a vaccine will be protective or not. Existing info on each MS medication type is discussed. Timing of vaccinations and medication dosing strategies covered such as for Ocrevus (ocrelizumab), Lemtrada (alemtuzumab) and Mavenclad (cladribine). Vaccines as a strategy to prevent or treat multiple sclerosis are explored; Epstein-Barr virus and BioNTech’s mRNA vaccine are considered.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Dr. Anne Cross          Photo: Matt Miller

Anne Cross MD is Professor of Neurology at Washington University in St. Louis and Dr. John Trotter MS Chair in Neuroimmunology. She did her neurology residency at George Washington University and multiple fellowships including at the Neuroimmunology Branch at NIH, at the Department of Virology/Molecular Biology at St. Jude Children’s Research Hospital in Memphis and in the Neuropathology Department at Albert Einstein College of Medicine in New York.  Her leading work in B cells in multiple sclerosis was recently recognized with the 2019 John Dystel Prize for MS Research.

Dr. Amit Bar-Or

Amit Bar-Or MD, FRCP, FAAN, FANA is Professor of Neurology at University of Pennsylvania Perelman School of Medicine.   He serves as Director of the Center for Neuroinflammation and Neurotherapeutics and Chief of the Division of Multiple Sclerosis and Related Disorders. He completed his undergraduate degree at McMaster in Hamilton, Ontario, Canada and medical degree from McGill University in Montreal, Canada. His neurology training was at Massachusetts General Hospital and fellowship at Brigham and Women’s Hospital, both Harvard Medical School programs.  Dr. Bar-Or’s research focuses on neuroimmune health and central nervous system inflammatory diseases across the age span. He runs a cellular and molecular neuroimmunology lab studying principles of immune regulation and immune-neural interaction in the context of injury and repair of the human central nervous system.

Jul 16 2020 MS Living Well Podcast: Taking Charge of Multiple Sclerosis

 

Photo (cropped): Leon Ell’ on Unsplash

Being diagnosed and living with multiple sclerosis is often overwhelming. Your MS journey might be challenging, frustrating and depressing at times.  On the bright side, superb MS care is available. This podcast lays out ways that you can take charge of MS and get the care you deserve.  Topics include finding the right neurologist for you and how to get reliable MS information.  Improve your communication with your doctor regarding worsening symptoms, progressive disease, MRI imaging and medication risks.  Making shared decisions regarding treatment with your neurologist highlighted.  If you feel more comfortable sticking with the treatment plan called “adherence,” you will be better off in keeping your MS in check. Financial assistance for treatments, MRI and office visits outlined. Expert information reviewed on diet, vitamin D, smoking, alcohol and exercise.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Cathy Chester

Cathy Chester was diagnosed with multiple sclerosis in 1986 and has become a leading national MS patient advocate.  Cathy is a graduate of Boston College with a Bachelor of Arts in English and Business and The Alfus Patient Advocate Certificate Program at The University of Miami.  Cathy’s An Empowered Spirit was named Top Health Blog by Healthline and Top Multiple Sclerosis Blog by Healthline and WEGO Health for several years. Cathy is a regular contributor to MultipleSclerosis.net and Multiple Sclerosis News Today.

Bhupendra Khatri MD

Bhupendra Khatri MD is the founding medical director of the Regional MS Center of the Center for Neurological Disorders in Milwaukee, one of the largest multiple sclerosis centers in the U.S. Dr. Khatri completed his residency in neurology at the Medical College of Wisconsin and fellowship at University of California in San Francisco.  He has been a principal investigator in numerous clinical trials, as well as an invited speaker at both national and international conferences. He has published over 55 papers in peer-reviewed journals and has contributed chapters to six books. In 2015 he was honored with the National Multiple Sclerosis Society Lifetime Achievement Award.  He is an accomplished book author and published the award-winning bestselling book, “Healing the Soul, Unexpected Stories of Courage, Hope and the Power of Mind.”

Jul 2 2020 MS Living Well Podcast: Overcoming Multiple Sclerosis Fatigue

Photo: Jen Theodore on Unsplash

Struggling with MS fatigue? You aren’t alone. Approximately 90% of people living with multiple sclerosis deal with fatigue. An overwhelming sense of tiredness can be disruptive at work and take away from your family time and social life. This podcast dives into the different causes of MS fatigue including disease impact on nervous system, medications and poor sleep.  Approaches to improve both mental and motor fatigue are highlighted including energy conservation strategies, exercise and workplace changes.  Fixing sleep issues can substantially help fatigue. Treatment options reviewed for causes of poor sleep including anxiety, restless legs, leg cramps, need to urinate overnight and sleep apnea.  Medication options for MS fatigue are reviewed including amantadine, modafinil, armodafinil and amphetamines.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Randy from Must Stop MS!

Randy from Must Stop MS!  was diagnosed with multiple sclerosis in November 2012.  Initially he was worried about his future: wheelchair? providing for his family?  Knowing how he felt after the diagnosis led him to become an advocate for this disease. He started Must Stop MS! on Facebook to provide support, new information regarding MS, and to raise awareness of the disease. Must Stop MS! quickly spread to Twitter and Instagram.  He started a weekly Twitter chat named #ChatMS that occurs every Monday at 7pm EST.  His mission is to bring the MS community together to help raise awareness, support each other, and provide hope.  Randy won’t stop until “we get that cure we all need.”

Enrique Alvarez MD PhD is an Assistant Professor of Neurology at the University of Colorado School of Medicine and cares for patients multiple sclerosis patients at the Rocky Mountain MS Center.  He was a graduate of the Medical Scientist Training program at the University of Colorado Denver and completed his neurology residency and neuroimmunology fellowship at Washington University in St. Louis.  He has a special interest in using biomarkers to customize treatments and patient care

Enrique Alvarez MD PhD

Jun 18 2020 MS Living Well Podcast: Sex and Multiple Sclerosis

Photo: Jeremy Banks on Unsplash

Sexual health is an important part of quality of life for many people.  Multiple sclerosis can cause new challenges and disrupt sexual relationships.  Positioning options, including pillows and slings, are reviewed that can help overcome weakness and stiffness of legs.  Factors that can be reduce a woman’s libido, or sexual drive, are addressed such as medications and hormone levels.  Ways to achieve a satisfying sexual relationship with disability from multiple sclerosis are discussed in terms of intimacy and foreplay.  Detailed solutions are presented such as stimulation and lubrication to overcome decreased or painful sensations with intercourse.

Up to 40% of men with multiple sclerosis can have low testosterone which can decrease libido.  An array of testosterone replacement options highlighted depending on whether a man still wants to father children or not.  Erectile dysfunction treatments discussed in depth including oral pills, intra-urethral suppositories, self-injection therapies, vacuum erection devices and penile implants.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Heather Raznick MSW LCSW

Heather Raznick MSW, LCSW is a psychotherapist in clinical practice in St. Louis. She obtained a Masters in Social Work from Washington University. She trained at the world-renowned Masters and Johnson Institute, where she studied clinical sex therapy under the direct supervision of legendary sexologist Dr. William Masters.  She provides academic and clinical training to residents and medical students as well as lectures at several area hospitals.  Heather shares her expertise on sexuality and wellness with community groups and organizations. She also frequently appears on radio interviews and television programs as a guest expert.  She is a member and has received certifications in multiple organizations including American Association of Sex Educators, Counselors and Therapists and the International Society for the Study of Women’s Sexual Health.

Etai Goldenberg MD

Etai Goldenberg MD  is the Director of Men’s Health at Urology of St. Louis.  Dr. Goldenberg completed his undergraduate degree at University of Michigan and medical school at Wayne State University School of Medicine in Detroit. His urological surgery residency was obtained at Washington University in St. Louis.   In addition, he completed a fellowship in male reproduction and sexual health at the Smith Institute for Urology in New York City.  He specializes in male sexual health, male reproduction, microsurgery, prosthetic urology and testosterone replacement.