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MS Living Well Podcast. Revolutionizing Multiple Sclerosis Care: B-Cell Therapy

Jan 30 2024

B cells traveling inside the circulation with red blood cells.

In a paradigm-shifting discovery, researchers uncovered that B cells, not T cells, wield significant influence on orchestrating neurological damage in MS. Join UCSF Professor Dr. Stephen Hauser as he shares the remarkable odyssey from hurdles to triumphs of developing B cell monoclonal antibody treatment for multiple sclerosis. Disease impact, safety concerns and personalization of MS treatment of these medications including Ocrevus (ocrelizumab), Kesimpta (ofatumumab) and Briumvi (ublituximab) are highlighted.

Brain-penetrant BTK inhibitor therapies that may offer more direct targeting of B cells within the central nervous system, potentially unlocking new possibilities in treating progressive forms of MS. Professor Heinz Wiendl explores the connection between Epstein-Barr virus infection of B cells and the initiation and progression of MS including trials investigating strategies to target EBV-infected B cells. Pioneering approaches like CAR-T therapy and brain shuttle techniques provide optimism for the next generation of MS treatment.

This podcast episode is sponsored by TG Therapeutics.

Barry Singer MD, Director of The MS Center for Innovations in Care, interviews:

Stephen Hauser MD

Dr. Stephen Hauser, Professor of Neurology at the University of California, San Francisco (UCSF) and Director of the UCSF Weill Institute for Neurosciences. He served as chairman of the Department of Neurology at UCSF for 25 years. Dr. Hauser is a graduate of MIT and Harvard Medical School. His work led to the development of B cell therapies for MS patients. Dr. Hauser is a member of the National Academy of Medicine and a fellow of the American Academy of Arts and Sciences. He authored The Face Laughs While the Brain Cries, his memoir about his 40-year quest to find a treatment for multiple sclerosis.

Heinz Wiendl MD

Dr. Heinz Wiendl, Professor of Neurology and Chair of the Department of Neurology at the University Hospital of Muenster in Germany. He completed his medical training in Erlangen, Germany, Basel, Switzerland and Durham, North Carolina at Duke.  He has published over 350 peer-reviewed journal articles. His research is dedicated to understanding immune regulation and the functional interaction between the immune and the nervous system.

BY: Barry Singer, MD DATE: January 30, 2024 TOPIC: Podcasts